abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

journal_title：British journal of cancer

authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...

journal_title：British journal of cancer

authors： Fleming IN,Manavaki R,Blower PJ,West C,Williams KJ,Harris AL,Domarkas J,Lord S,Baldry C,Gilbert FJ

更新日期：2015-01-20 00:00:00

abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

journal_title：British journal of cancer

authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

更新日期：2015-01-06 00:00:00

abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...

journal_title：British journal of cancer

authors： Miah AB,Schick U,Bhide SA,Guerrero-Urbano MT,Clark CH,Bidmead AM,Bodla S,Del Rosario L,Thway K,Wilson P,Newbold KL,Harrington KJ,Nutting CM

更新日期：2015-01-06 00:00:00

abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...

journal_title：British journal of cancer

authors： de Aberasturi AL,Calvo A

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown. METHODS:Two cohorts were prospectively enr...

journal_title：British journal of cancer

authors： Lewin J,Khamly KK,Young RJ,Mitchell C,Hicks RJ,Toner GC,Ngan SY,Chander S,Powell GJ,Herschtal A,Te Marvelde L,Desai J,Choong PF,Stacker SA,Achen MG,Ferris N,Fox S,Slavin J,Thomas DM

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:The most significant problem of intra-arterial chemotherapy for advanced paranasal sinus carcinomas and residual cancers supplied by internal carotid artery (ICA) and involving the skull base is the lack of salvage therapies. OBJECTIVE:The objective of the study was to evaluate the usefulness of intra-arter...

journal_title：British journal of cancer

authors： Yokoyama J,Ohba S,Fujimaki M,Anzai T,Kojima M,Ikeda K,Suzuki M,Yoshimoto H,Inoue K

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...

journal_title：British journal of cancer

authors： Haguenoer K,Sengchanh S,Gaudy-Graffin C,Boyard J,Fontenay R,Marret H,Goudeau A,Pigneaux de Laroche N,Rusch E,Giraudeau B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:The randomised phase III TURANDOT trial compared first-line bevacizumab-paclitaxel (BEV-PAC) vs bevacizumab-capecitabine (BEV-CAP) in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). The interim analysis revealed no difference in overall survival (OS; primary end point) between treatment ar...

journal_title：British journal of cancer

authors： Brodowicz T,Lang I,Kahan Z,Greil R,Beslija S,Stemmer SM,Kaufman B,Petruzelka L,Eniu A,Anghel R,Koynov K,Vrbanec D,Pienkowski T,Melichar B,Spanik S,Ahlers S,Messinger D,Inbar MJ,Zielinski C

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...

journal_title：British journal of cancer

authors： Zheng G,Du L,Yang X,Zhang X,Wang L,Yang Y,Li J,Wang C

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. TERTp-mut creates a binding site for Ets/TCF transc...

journal_title：British journal of cancer

authors： Labussière M,Di Stefano AL,Gleize V,Boisselier B,Giry M,Mangesius S,Bruno A,Paterra R,Marie Y,Rahimian A,Finocchiaro G,Houlston RS,Hoang-Xuan K,Idbaih A,Delattre JY,Mokhtari K,Sanson M

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...

journal_title：British journal of cancer

authors： Bunch KJ,Vincent TJ,Black RJ,Pearce MS,McNally RJ,McKinney PA,Parker L,Craft AW,Murphy MF

更新日期：2014-10-28 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where su...

journal_title：British journal of cancer

authors： Lear JT,Corner C,Dziewulski P,Fife K,Ross GL,Varma S,Harwood CA

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...

journal_title：British journal of cancer

authors： Schmitt J,Noble A,Otsuka M,Berry P,Maitland NJ,Rumsby MG

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...

journal_title：British journal of cancer

authors： Nitta T,Mitsuhashi T,Hatanaka Y,Miyamoto M,Oba K,Tsuchikawa T,Suzuki Y,Hatanaka KC,Hirano S,Matsuno Y

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia. This has important clinical implications; however, the mechanisms underly...

journal_title：British journal of cancer

authors： Huang H,Benzonana LL,Zhao H,Watts HR,Perry NJ,Bevan C,Brown R,Ma D

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...

journal_title：British journal of cancer

authors： Znojek P,Willmore E,Curtin NJ

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared with cytology for triage testing in hrHPV-positive women. Moreover, feasibility of DNA methylation a...

journal_title：British journal of cancer

authors： Boers A,Bosgraaf RP,van Leeuwen RW,Schuuring E,Heideman DA,Massuger LF,Verhoef VM,Bulten J,Melchers WJ,van der Zee AG,Bekkers RL,Wisman GB

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used we...

journal_title：British journal of cancer

authors： Chiang PH,Chen CH,Shen YC

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...

journal_title：British journal of cancer

authors： Massoner P,Thomm T,Mack B,Untergasser G,Martowicz A,Bobowski K,Klocker H,Gires O,Puhr M

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age c...

journal_title：British journal of cancer

authors： Brustugun OT,Møller B,Helland A

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

journal_title：British journal of cancer

authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...

journal_title：British journal of cancer

authors： Kriege M,Hollestelle A,Jager A,Huijts PE,Berns EM,Sieuwerts AM,Meijer-van Gelder ME,Collée JM,Devilee P,Hooning MJ,Martens JW,Seynaeve C

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:We analysed critically the potential usefulness of RNA- and DNA-based biomarkers in supporting conventional histological diagnostic tests for prostate carcinoma (PCa) detection. METHODS:Microarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 ...

journal_title：British journal of cancer

authors： Paziewska A,Dabrowska M,Goryca K,Antoniewicz A,Dobruch J,Mikula M,Jarosz D,Zapala L,Borowka A,Ostrowski J

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative ...

journal_title：British journal of cancer

authors： Wallace D,Walker K,Kuryba A,Finan P,Scott N,van der Meulen J

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patie...

journal_title：British journal of cancer

authors： Feliu J,Salud A,Safont MJ,García-Girón C,Aparicio J,Vera R,Serra O,Casado E,Jorge M,Escudero P,Bosch C,Bohn U,Pérez-Carrión R,Carmona A,Martínez-Marín V,Maurel J

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...

journal_title：British journal of cancer

authors： Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...

journal_title：British journal of cancer

authors： Gujam FJ,Edwards J,Mohammed ZM,Going JJ,McMillan DC

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...

journal_title：British journal of cancer

authors： Je Y,De Vivo I,Giovannucci E

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...

journal_title：British journal of cancer

authors： Hendrikx JJ,Lagas JS,Wagenaar E,Rosing H,Schellens JH,Beijnen JH,Schinkel AH

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

journal_title：British journal of cancer

authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited. METHODS:From the US SEER-Medicare database, 44,191 NHL, 1832 HL and 200,000 population-ba...

journal_title：British journal of cancer

authors： Anderson LA,Atman AA,McShane CM,Titmarsh GJ,Engels EA,Koshiol J

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...

journal_title：British journal of cancer

authors： Mao YP,Zhou GQ,Liu LZ,Guo R,Sun Y,Li L,Lin AH,Zeng MS,Kang TB,Jia WH,Shao JY,Mai HQ,Ma J

更新日期：2014-05-27 00:00:00